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Anti -Cyclin E1 Rabbit pAb

價格: 在線咨詢
貨號:
KT011864
產品規格:
100 μL
Applications:
IHC/IF
Species:
H,M,R
購買數量:
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產品詳情 操作說明 注意事項

Product Information


Description

Cyclin E1 rabbit polyclonal antibody

Protein full name

G1/S-specific cyclin-E1

Synonyms

CCNE1, CCNE, pcyclin E1, Cyclin E1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Cyclin E1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P24864, Q61457




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Human, Mouse, Rat

1: 250-1: 1000

colon, placenta, testis




Background


The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.




Images


Picture 1.png

Immunohistochemistry of paraffin embedded human placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens)

Picture 2.png

Immunohistochemistry of paraffin embedded mouse testis using cyclinE1 (GB111937) at dilution of 1:500 (300x lens)

Picture 3.png

Immunohistochemistry of paraffin embedded mouse colon using cyclinE1 (GB111937) at dilution of 1:500 (400x lens)

Picture 4.png

Immunohistochemistry of paraffin embedded mouse placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens)

Picture 5.png Immunohistochemistry of paraffin embedded rat testis using cyclinE1 (GB111937) at dilution of 1:500 (300x lens)

Picture 6.png

Immunohistochemistry of paraffin embedded rat placenta using cyclinE1 (GB111937) at dilution of 1:500 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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