This
gene encodes one of several forms of glutamic acid decarboxylase,
identified as a major autoantigen in insulin-dependent diabetes. The
enzyme encoded is responsible for catalyzing the production of
gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this
enzyme has been identified in the human pancreas since it has been
identified as an autoantibody and an autoreactive T cell target in
insulin-dependent diabetes. This gene may also play a role in the stiff
man syndrome. Alternative splicing results in multiple transcript
variants that encode the same protein.
Images
Western blot analysis of GAD65 (GB12562) at dilution of 1: 1000
Immunohistochemistry of paraffin embedded mouse cerebellum using GAD65 (GB12562) at dilution of (300x lens)
Immunohistochemistry analysis of paraffin-embedded mouse brain using GAD65 (GB12562) at dilution of 1: 1000(350x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .