S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
Images
Immunohistochemistry of paraffin embedded mouse spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens)
Immunohistochemistry of paraffin embedded rat spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens)
Immunofluorescence of paraffin embedded human ovarian cancer using S100A8 (GB11421) at dilution of 1:1500 (400x lens)
Immunofluorescence of paraffin embedded mouse spleen using S100A8 (GB11421) at dilution of 1:1500 (400x lens)
Immunofluorescence of paraffin embedded rat stomach using S100A8 (GB11421) at dilution of 1:1500 (400x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .