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產品詳情
操作說明
注意事項
Product Information
|
Description |
MLK4 rabbit polyclonal antibody |
|
Protein full name |
Mitogen-activated protein kinase kinase kinase 21 |
|
Synonyms |
Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Map3k21, Kiaa1804, Mlk4 |
|
Immunogen |
Recombinant protein corresponding to Mouse MLK4 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
110 kDa |
|
Observed MW. |
120 kDa |
|
Uniprot ID |
Q8VDG6, D4A454 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
heart |
Background
MLK4 belongs to the MAP kinase subfamily. The MLK family members are characterized by the presence of signature sequences of Ser/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.
Images
|
|
Western blot analysis of mlk4 at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室